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Objective:To investigate the efficacy and safety of modular flexible ureteroscopic lithotripsy (M-FURL) in treatment of diabetic patients with kidney stones.Methods:Sixty patients with diabetes and kidney stones admitted to the Department of Urology, Xindu District People’s Hospital of Chengdu were selected as the observation group, and 78 patients with diabetes without kidney stones who were treated in our hospital during the same period were selected as the control group. M-FURL was performed to compare the operation of the two groups of patients.Results:Compared with the control group, fasting blood glucose and blood glucose level at 2h after meals in the observation group were significantly increased ( P<0.05) ; and the ratio of uric acid stones and calcium oxalate stones in the observation group was significantly higher than that ine the control group ( P<0.05) ; The two groups of patients were treated with M-FURL, and there was no statistically significant difference in stone clearance rate, total stone clearance rate, or complication rate ( P>0.05) ; At the same time, the difference in operation time and intraoperative blood loss between the two groups had no statistical significance ( P>0.05) ; while the hospital stay of the observation group was significantly longer than that of the control group ( P<0.05) . Conclusions:Patients with kidney stones and diabetes are more likely to have calcium oxalate stones and uric acid stones. M-FURL treatment in patients with diabetes and kidney stones is ideal and safe. Combining diabetes will not affect the effect of surgery.
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Gastric cancer, a common malignant tumor in digestive system with high morbidity as well as mortality rate, is insidious at the onset and lack of effective treatments so far. A growing number of studies have shown that exosome-derived miRNAs play an important role in the occurrence and development of gastric cancer. Autocrine exosome miRNAs from gastric cancer cells regulated tumor growth, recurrence, metastasis and drug resistance, etc. Moreover, exosomal miRNAs in the tumor microenvironment can be delivered into cancer cells to facilitate intercellular communication, thus affecting the progress of gastric cancer. Due to exosomes, which were released into circulation from tumor cells, contain abundant, specific and stable miRNAs, exosome-derived miRNAs have a great potential to be used as novel diagnosis biomarkers and treatment targets of gastric cancer.(Chin J Lab Med, 2018, 41: 499-502)
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Malignant tumors of the digestive system , with high morbidity and mortality rate , are insidious at the onset and lack of effective treatments so far .Interleukin-22 (IL-22) is one of the members of the IL-10 cytokine family discovered in recent years and was originally called IL-10-associated T cell differentiation inducing factor (IL-TIF).IL-22 expression is elevated in various digestive system malignant tumors, and increased IL-22 expression is associated with tumor progression and poor prognosis .Studies on the molecular mechanism revealed that IL-22 initiates a series of downstream signaling pathways such as JAK/STAT and MAPK, by acting on the IL-22 receptor, inducing tumorigenesis.IL-22 is expected to be a novel diagnostic biomarker and therapeutic target of digestive system malignant tumor .
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Objective To describe the status quo of influencing factors of resilience among caregivers of cancer patients, and to analyze the influence path. Methods A total of 407 caregivers of cancer patients in tertiary hospital in Xinjiang uygur autonomous region were recruited by cross-sectional survey method. Caregivers were investigated using the Connor-Davidson Resilience Scale, the Social Support Rating Scale, the Self-Efficacy Questionnaire, the Coping Modes Questionnaire, Positive and Negative Affect Schedule. Results The overall resilience score was (67.86 ± 11.36) points. Multiple linear regression analysis showed that caregivers′resilience was affected by subjective support,objective support, the self-efficacy, positive and negative coping modes, positive affect (P<0.01) and explained 44.9% of all the variation. subjective support, objective support and the self-efficacy directly and indirectly influenced resilience of caregivers of cancer patients. Conclusion Caregivers of cancer patient have a relatively high resilience level. subjective support and objective support were important factors.
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Objective To explore the cooperative mechanism of hospital research management and ethics review.Methods Through the analysis of current ethical conditions,as well as the relationship between hospital research management and ethical review,study on how to integrate them during the management of scientific research project.Results Research management and ethical review have different emphasis from different perspectives,however,both of them serve for research projects which makes inseparable connections.Conclusions Hospital research management and ethical review can be synergistic,according to which the management of scientific research projects will be more reasonable and scientific.
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Objective To explore the moderating and mediating role of social support in the relationship between caregiver burden and Negative Affect in Caregivers of cancer patients. Methods A total of 407 caregivers of cancer patients in tertiary hospital in Xinjiang were recruited by cross-sectional survey method. Caregives were investigated using Caregiver Burden Scale for Cancer patients, Positive and Negative Affect Schedule, theSocialSupport Rating Scale. Results Social support mediated the relationships between caregiver burden andnegative effect, which accounted for 6.41％ of the total variance. The interactive effects of caregiver burden× social support on thenegative affect was significant(β=0.003, t=2.782, P<0.01). Conclusions Social support plays a mediatingand moderating role on the relationships between caregiver burden and negative effect.
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Objective Innovate scientific research management thinking,explore new scientific research management models,and enhance hospital's competitiveness.Methods The hospital insistently adheres to the path of science and education hospital development in the practice of scientific research management,and takes measures of creating academic atmosphere,innovating management concept,rationalizing incentive measures,setting supporting policies,and so on.Results The hospital has gained certain progress in the fields of key discipline construction,research project,talent plan,scientific and technological achievements,etc.Conclusions The path of science and education hospital development plays an important role in the further healthy and sustainable development of hospital.